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(MOV 26066 kb) Purinergic receptor and connexin hemichannel signaling mediate the innate immune response to compression injury (download MOV Part 1: Representative time lapses were captured in a CX3CR1 mice pretreated transcranially with P2Y12, P2Y6, P2X4, or P2X7 receptor antagonists and imaged beginning 5 min post-compression injury

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95,96 Excessive endoplasmic reticulum stress leads to an increase in trypsin activity, which in turn stimulates PAR2 and PAR4 receptors, increases intestinal permeability, destroys the function of the intestinal barrier, and promotes the development of inflammatory processes

Ong JS, Hwang LD, Cuellar-Partida G, Martin NG, Chenevix-Trench G, Quinn MCJ, Cornelis MC, Gharahkhani P, Webb PM, MacGregor S, Association Consortium OC

10.1007/s11901-006-0019-7 [DOI] [PubMed] [Google Scholar] Castelli M

In parallel, we analyzed transcriptomic changes in the -oxidation pathway, a major route for fatty acid utilization in ILC2s ( Supplementary Figures 6A, B )